The best play, if you can isolate a weaker player is to PLAY THE OPPOSITE of his/her play.
Option #1 - Weak player is in every pot betting too much on too little. Here, I would stay out of the way until I had a nice hand and then call his raises to the river. On the river, check raise or re-raise. So, I check, he bets, I call - opposite.

Option #2 - Weak player won't bet on the nuts - even. Over play every hand for a long term profit. If he checks, I bet. If he bets, I ONLY call or fold. - opposite.

Remember to isolate the weak player now!

If the chip leader has the chance to enter the action, everything changes. Mind your position and keep in mind that no strategy is 100%. If the play is profitable over time, then you'll lose some but win many more. Enough profitable plays = profitable player.
TheSyphon
